Melanoma EVs conveying onco-fetal insulin-like growth factor 2 mRNA-binding protein 1, involved in post-transcriptional regulation of transcripts encoding proteins for cell adhesion, migration, and ECM remodeling [e.g., CD44, a ligand for HA, osteopontin (OPN), collagens, and MMPs (168)], promoted ECM remodeling and FN deposition (34). This evidence concerns the gene SPP1 and melanoma.