MMP2 and neoplasm: Overexpression of ECM remodeling enzymesIncreased secretion and activation of enzymes that degrade the ECM: MMPs (MMP-1, MMP-2, MMP-9, and others), ADAMs (serine and threonine proteases), proteases released by neutrophils, NET formationDysregulated proteolysis leading to excessive ECM degradation and remodeling, enhanced tumor angiogenesis, invasion, and metastasis