Increased ECM deposition of collagen (types I, III, and IV), FNs, HA, and altered levels of elastin, as well as PGs (decorin, biglycan, lumican, and fibromodulin) depending on the cancer typeIncreased TNC impacts tumor growth and metastasis by modulating the interactions of integrins and syndecans with FNs. The gene discussed is TNC; the disease is cancer.