Overexpression of ECM remodeling enzymesIncreased secretion and activation of enzymes that degrade the ECM: MMPs (MMP-1, MMP-2, MMP-9, and others), ADAMs (serine and threonine proteases), proteases released by neutrophils, NET formationDysregulated proteolysis leading to excessive ECM degradation and remodeling, enhanced tumor angiogenesis, invasion, and metastasis. The gene discussed is MMP1; the disease is neoplasm.