TIMP1 and familial pancreatic carcinoma: These studies revealed higher levels of cancer-related proteins involved in ECM remodeling and ECM-mediated interactions (e.g., TIMP-1, MMP-8, and TSP-1) compared to subcutaneous fat, suggesting that omental fat could reprogram pancreatic cancer cells toward a more aggressive and invasive phenotype, marked by increased levels of ECM proteins and adhesion molecules (208).