PTPRC and neoplasm: Regions in which stromal cells were adjacent to tumor (‘tumor-proximal stroma’), distant from tumor (‘tumor-distal stroma’) or enriched for CD45+ immune cells (‘immune enriched’) were then selected and 4 areas (‘regions of interest’; ROI) within each of these 3 domains were selected from each patient for assessment using the NanoString GeoMx Digital Spatial Profiler (DSP) platform (Figure 1).