AQP8 and infection: The most highly downregulated gene during infection was the cytochrome p450 family protein-encoding gene Cyp2c55, which has been previously reported.10Dra (Slc26a3) was the second-most downregulated gene, followed by other solute and water transporters Aqp8, Clca1, Slc20a1, Slc26a2, Nhe3 (Slc9a3), and Sglt1 (Slc5a1).