NHE3 and DRA are depleted during human CDI and are predicted factors in causing diarrhea.18–20 Given our observation that both TcdA and TcdB contribute to weight loss and diarrhea, we hypothesized that each toxin could have a different effect on the expression of ion transporters implicated in diarrhea. This evidence concerns the gene SLC9A3 and clostridium difficile infection.