PTEN and urinary bladder cancer: For example, a mechanism for aberrant cell proliferation in bladder cancer implicates a pathway in which high METTL3 expression enhances DGCR8 recognition and binding of m6A-modified pri-miR221/222 which, in turn, potentiates miR221/222 maturation and subsequent reduction in levels of phosphatase and tensin homolog (PTEN), a known target of miR221/222 [58].