CD40LG and Alzheimer disease: In contrast, the level of IgM against acrolein-Aß17-28 and the ratio of both anti-acrolein-Aß1-16 and anti-acrolein-Aß17-28 IgM antibodies to acrolein adducts were reduced largely in AD-M group compared to MetS (p < 0.001) with AUC values from 0.693 to 0.755 in ROC analyses (Fig. 7).