ATP2A2, encoding for the enzyme sarco(endo)plasmic reticulum calcium-ATPase 2 (SERCA2), responsible for Ca2+ pumping action showed decreased expression (1.5-fold, p < 0.05) in patient DCM-O-iPSCs-CMs compared to control DCM-C- iPSCs-CMs and no change in DCM-R- iPSCs-CMs (Fig. 3J). This evidence concerns the gene ATP2A2 and familial dilated cardiomyopathy.