Muhammad et al. [20] described a large Bedouin family presenting with a severe recessive DCM and LVNC and harboring a mutation in pleckstrin-homology-domain-containing family member 2 (PLEKHM2) gene (cDNA2156_2157delAG), encoding pleckstrin homology domain-containing family M member 2, an autophagy regulator [20]. This evidence concerns the gene PLEKHM2 and familial dilated cardiomyopathy.