CASQ2 and familial dilated cardiomyopathy: The patient-derived iPSC-CMs exhibited a marked decrease in the expression of Calsequestrin 2, (CASQ2), a protein involved in the storage and transport of calcium ions [31, 32] (Fig. 3K); fivefold and sixfold decrease in DCM-O- iPSCs-CMs and DCM-R- iPSCs-CMs compared to control DCM-C- iPSCs-CMs (p < 0.05 in both).