However, this study has been challenged because the interaction p values for Hp phenotype and strict glycemic control on CVD outcomes did not reach significance in Carew et al’s study (the p values of CHD, CVD, non-fatal MI, fatal CVD and total mortality is 0.059, 0.126, 0.212, 0.253 and 0.110 respectively), the article failed to reject the null hypothesis of identical cardiovascular effects of intensified glycemic control in Hp2-2 and Hp1 carriers [131]. Here, HP is linked to coronary artery disorder.