Later, Cahill et al. further developed this conclusion in another study, revealing that compared with HbA1c level < 6.5%, the risk rate of CHD for HbA1c level ≥ 6.5% is significantly elevated in patients with Hp 2-2 genotype over full follow-up and the first half of follow-up, while individuals with Hp2-2 phenotype and HbA1c level < 6.5% didn’t have significant increased CHD risk [121]. Here, HP is linked to coronary artery disorder.