To investigate the role of hepatic NCOR1 in atherosclerosis, we generated hepatocyte-specific Ncor1 knockout mice on an atherosclerosis-prone low-density lipoprotein receptor knockout (Ldlr−/−) background; further referred to as L-Ncor1Hep−/− and control L-Ncor1Hep+/+ (Additional file 1: Fig. S1 and S2). This evidence concerns the gene VLDLR and atherosclerosis.