To compare subsequent cardiovascular risks, including heart failure, myocardial infarction, angina pectoris, stroke, and atrial fibrillation, following the use of different SGLT2 inhibitors, Suzuki et al. analyzed a large-scale real-world dataset comprising approximately 25,000 patients with diabetes mellitus who were newly prescribed SGLT2 inhibitors (empagliflozin, dapagliflozin, canagliflozin, ipragliflozin, tofogliflozin, and luseogliflozin) in Japan. This evidence concerns the gene SLC5A2 and atrial fibrillation.