This analysis of an interactive, immersive, case-based, multidisciplinary medical education initiative focused on selected retinal diseases of AMD, DR/DME, and RVO yielded strong, positive outcomes in improved knowledge and competence, as well as real-world impact evidenced by robust practice behavior change as reflected in increased medical claims for anti-VEGF therapies, a guideline-recommended treatment. Here, VEGFA is linked to age-related macular degeneration.