To help address practice and knowledge gaps about retinal diseases and to better explore the impact of CE on knowledge and performance outcomes among eye care providers and educators, this test and control matched pair analysis examined change in knowledge/competence and practice behavior change, operationalized by change in guideline-recommended use of anti-VEGF agents, among VISION RELIEF learners over a 17-month span from 2020 to 2021. This evidence concerns the gene VEGFA and Abnormal retinal morphology.