Prognostic analysis found that patients with high mRNA expression of PSMD2, PSMD3, PSMD4, PSMD5, PSMD8, PSMD11, PSMD12, and PSMD14 have poor prognosis; among these, PSMD8 showed the best prognostic value in patients with serous ovarian cancer. The gene discussed is PSMD4; the disease is ovarian serous adenocarcinoma.