To validate these findings, we collected patients with ICC from 2008 to 2019 who underwent surgery in Sir Run Run Shaw Hospital (N = 53) for transcriptome analyses and found decreased levels of IGFBP4, which were positively correlated with miR-122-5p levels (Fig. 3i, j). The gene discussed is IGFBP4; the disease is intrahepatic cholangiocarcinoma.