EDN1 and Schnyder corneal dystrophy: In each of the three models, patients in high ET-1 group remained at significantly higher risk for all-cause mortality (model 1: HR: 2.22; 95% CI 1.63–3.02; p < 0.001; model 2: HR: 2.13; 95% CI 1.56–2.92; p < 0.001; model 3: HR: 2.06; 95% CI 1.5–2.83; p < 0.001), CV death, non-CV death and SCD (Table 2).