Patients with high ET-1 levels were older (69 IQR [63, 75] vs 66 IQR [60, 72], p < 0.0001), were more often women (36.4% vs 28.2%, p < 0.0001) and had more frequently T2D (58.5% vs 30.8%, p < 0.0001) (Table 1). The gene discussed is EDN1; the disease is type 2 diabetes mellitus.