The qPCR analysis of our cells also showed a significant upregulation of GADD45b expression in our tumor (ΔCt—EtOH 7.576 ± 0.3837 & 4-OHT 5.863 ± 0.2744; P = 0.0110), clone 5 (ΔCt—EtOH 10.43 ± 0.4973 & 4-OHT 7.695 ± 0.0909; P = 0.0017), and MEF (ΔCt—EtOH 7.429 ± 0.1711 & 4-OHT 5.056 ± 0.0966; P = 0.0003) cells after the loss of SMG7 (see Fig. 3.i,j,k). The gene discussed is GADD45B; the disease is neoplasm.