SMG7 and neoplasm: The loss of SMG7 significantly decreased the tumor growth of our RMS cells, as exhibited by a ~ 54% lower average tumor mass in the 4-OHT treated group (EtOH 1.675 g ± 0.1264 & 4-OHT 0.7728 g ± 0.09637; P = 0.000007) (see Fig. 4a,b).