The loss of SMG7 induced a significant increase in the mRNA level of p21 in our tumor (ΔCt—EtOH 5.407 ± 0.2466 & 4-OHT 4.329 ± 0.3210; P = 0.0374) and clone 5 (ΔCt—EtOH 6.239 ± 0.4141 & 4-OHT 4.986 ± 0.2477; P = 0.0408) cells, as well as a clear upregulation of p21 protein (see Fig. 2g and Supplemental Fig. S4). This evidence concerns the gene SMG7 and neoplasm.