SMG7 and neoplasm: Furthermore, qPCR of our cells showed a significant upregulation of GAS5 expression in our tumor (ΔCt—EtOH 1.033 ± 0.1285 & 4-OHT − 7.754 ± 0.4231; P = 0.0007), clone 5 (ΔCt—EtOH 1.409 ± 0.2187 & 4-OHT − 1.987 ± 0.1848; P = 0.00002), and MEF (ΔCt—EtOH 6.027 ± 0.0335 & 4-OHT 2.554 ± 0.1978; P = 0.00007) cells after the loss of SMG7 (see Fig. 3g,h,k).