Participants carrying the homozygous AA genotype had a 46% lower risk of CRC compared to those who carried the G allele (OR = 0.54; 95% CI = 0.30–0.97; p = 0.038), suggesting that the AA genotype of the ISX rs5755368 polymorphism may be a protective factor against CRC occurrence. This evidence concerns the gene ISX and colorectal carcinoma.