As mentioned in the Introduction, while the intestinal-specific knock-out of Pygo1/2 or Bcl9/B9l has little impact on normal intestinal homeostasis, these knock-out conditions suppressed tumorigenesis and extended the disease-free life of Apc-mutant mice owing to a normalization of the transcriptional program within their intestinal tumors from stem cell-like to differentiated16,45,46. Here, APC is linked to intestinal neoplasm.