BANF1 and neoplasm: Furthermore, as mentioned above, the effects of Pygo or LDB loss on Wnt target genes can be complicated by the fact that a single ChiLS core complex can bind simultaneously to Pygo through one arm and to another NPF-containing protein such as ARID1 through the other: recall that ARID1 is the DNA-binding subunit of the chromatin remodeling BAF complex which switches target genes between ON and OFF states, behaving as a repressor of Wnt responses in flies and as an important tumor suppressor in humans25,29.