IFNA1 and pemphigus foliaceus: In agreement with previously reported data in advanced melanoma33 and in spite of the small sample size preventing to detect substantial differences at the transcriptomic level, we observed that PF tumors were enriched at baseline for gene sets linked to response to ICI, i.e., IFN-related pathways in multiple solid tumors33–35; whereas, PD patients were enriched in EMT, angiogenesis-related and KRAS gene sets, previously associated with resistance to ICI36–39.