To address whether the preexisting immune-reactive landscape observed in PF patients is endowed with antigen-presenting cells (APCs) to efficiently prime T cells, we explored the expression of CD28 and PD-1 on CD8+ T cells and CD86 on the CD11c+ compartment (Fig. 3G, H and Supplementary Fig. 2F). This evidence concerns the gene CD86 and pemphigus foliaceus.