Regarding the immunological correlates of clinical outcome, and in line with the transcriptomic data, we observed that PF patients display higher numbers of proliferating, Ki67+ cytotoxic GZMB+, FOXP3+ regulatory T cells in the stroma compared to the tumor, along with higher PD-L1+ expression on immune cells in the stroma. Here, GZMB is linked to pemphigus foliaceus.