Indeed, in the context of amyloidosis, Gal-3 can act as an endogenous ligand for TREM2 (Kd = 450 nM)46, with higher affinity than for TLR4 (Kd = 1 μM)42, suggesting that in the context of TASTPM inflammatory arthritis pain, Gal-3 might bind TREM2 as TLR4 is significantly downregulated. Here, TLR4 is linked to amyloidosis.