ACO2 and infection: Among them, RNAi targeting aconitase 2 (aco-2), which encodes mitochondrial aconitase that catalyzes the conversion of citrate to isocitrate, greatly increased the survival of animals upon infection with Pseudomonas aeruginosa PA14, Gram-negative pathogenic bacteria (up to 102%, Fig. 1b, c, and 4i).