We genetically inhibited mammalian ACO2 using siRNA knockdown (ACO2 KD) (Fig. 7b and Supplementary Fig. 12a), and found that ACO2 KD increased the viability of HeLa cells upon infection with pathogenic S. aureus (Fig. 7c), consistent with the data using C. elegans (Fig. 1k, m). This evidence concerns the gene ACO2 and infection.