Therefore, we asked whether syntabulin affects epilepsy by regulating the synaptic trafficking of STX1A/1B, since STX1B and STX1A are highly homologous and both are major syntaxin family members mediating the release of presynaptic transmitters [15, 16], and the functional abnormalities of both are related to epilepsy [23, 24]. The gene discussed is SYBU; the disease is epilepsy.