As previously described, genetic alterations reinforced the distinction between those two tumor types: mutations or fusions of BRAF (with another fusion partner than KIAA1549) or RAF1 for DIG/DIA [7], and fusions implicating the RTK genes for IHG [2, 11, 18, 19, 20, 21, 22]. The gene discussed is KIAA1549; the disease is neoplasm.