RUNX1 and acute myeloid leukemia: However, analysis of the somatic mutations in AML with high Haem p53Score does reveal a significant under-representation of mutations in RUNX1/CEBPA transcription factor complex, as well as mutations and translocations that act through inhibition of differentiation (RUNX1-RUNX1T1, PML-RARA, MLL rearrangements) (Figure 5I; Table S5).