Our Haem p53Score is also able detect increased p53 activity in multiple hematopoietic progenitor populations from human FA patients based on a published dataset (Figure S5E).52 Interestingly, the human FA progenitor cells exhibited MYC downregulation in p53-activated progenitor cells,52 which we also observe in Aldh2−/− Fancd2−/− HSPCs (Figure S5D). Here, FANCD2 is linked to Friedreich ataxia.