For example, in the case of BC, there is a positive association between the lncRNA HOTAIR and metastasis [26]; HOTAIR acts as a miR-20a-5p sponge, significantly impacting the migration and invasion of tumor cells by modulating the HOTAIR/miR-20a-5p/HMGA2 pathway [27]. The gene discussed is HMGA2; the disease is neoplasm.