ACKR3 and posterior cortical atrophy: To characterize the downstream molecular pathways of CXCR7 in advanced PCa, we performed CXCR7 knockdown (KD) in LNCaP-EnzR and C4-2B-EnzR cells, which are, respectively, LNCaP and C4-2B cells that have developed resistance to enzalutamide after several months of exposure.