Moreover, the inflammatory acinar cells within the pancreas contribute to PNI through the production of pancreatitis-associated protein (pancreatitis-associated protein/regenerating islet-derived protein 3 alpha) (PAP/REG3A), which activates the JAK/STAT signaling pathway in cancer cells [86] (Fig. 2C). The gene discussed is REG3A; the disease is pancreatitis.