IL4 and neoplasm: On the other hand, cytokines such as IL‐4, IL-10, and IL-13 can induce macrophage polarization to the M2 subtype, which is not only crucial for the onset of the classical Th2 immune response (i.e., humoral immunity, wound healing, tissue remodeling), but it is also key for the production of anti-inflammatory cytokines such as IL-10 and TGF‐β which foster tumor evolution.