By comparing the immune cell repertoire in lung adenocarcinoma driven by ALK fusions and lung adenocarcinoma driven by by EGF-R mutations distinct mechanisms of immune suppression were identified with a higher abundance of regulatory T cells (Tregs) in ALK+ tumors and a lower abundance of cytotoxic T cells in EGF-R+ tumors. This evidence concerns the gene ALK and lung adenocarcinoma.