We previously reported that the MYC-MAX heterodimer binds to E-box motifs and activates gene expression, whereas the heterodimer between MAX and MNT promotes transcriptional repression of cyclin D1.5 In this work, we discovered that MAX interacts with other proteins such as β-catenin, IL-6, and HMGB1 in CCA liver tissues, which in turn modulates transcription. This evidence concerns the gene MYC and cholangiocarcinoma.