CSNK2 is a highly conserved serine/threonine kinase involved in tumor biology by regulating cell proliferation, cell cycle progression, apoptosis, metabolism, and invasiveness.8 CSNK2A1 is highly expressed in cancer tissues such as gastrointestinal tract, head and neck, kidney, and prostate cancers.9 In this work, we found that CSNK2A1 protein levels were higher in hepatic cells from liver tissues with CCA. Here, CSNK2A1 is linked to cholangiocarcinoma.