Co-IP of HMGB1, WNT5B, C-MYC, β-catenin, and IL-6 with MAX was enhanced in CCA liver tissues compared with controls (Figure 3A, Supplemental Tables S2, http://links.lww.com/HC9/A363 S3, http://links.lww.com/HC9/A364). This evidence concerns the gene WNT5B and cholangiocarcinoma.