C-MYC and MNT proteins in liver tissues rapidly degrade under normal conditions, with half-lives of 20 to 30 and 15 to 25 minutes, respectively.29 In contrast, MAX is a highly stable protein with a half-life of 24 hours in MzChA-1 cells and 48 hours in cholangiocytes isolated from liver tissues with CCA. This evidence concerns the gene MYC and cholangiocarcinoma.