It is also known that cancer‐associated fibroblasts (CAF) secrete M‐CSF, IL‐6 and MCP‐1 factors, which facilitate macrophage inflammation and polarization, while M2 produce TGF‐β, stimulating the conversion of endothelial cells to mesenchymal cells and increasing the responsiveness of CAF, thus strengthening the aggressiveness of cancer cells.36 This evidence concerns the gene TGFB1 and cancer.