Subsequently, a thirteen-gene signature containing ACTB, BAD, CYP1A1, ESRRA, FECH, LRRC27, MIF, MMP9, NOS1, PDE4D, PDE5A, SREBF1,and WARS1 was developed through univariate and multivariate Cox analyses, LUSC patients with COVID-19 may benefit from independent prognostic variables. This evidence concerns the gene PDE4D and COVID-19.