In addition, we chose the top six targets in the PPI network as well as essential proteins connected to COVID-19/LUSC for molecular docking with naringenin. There were significant variations in the expression of the top six target genes, which included AKT1, TP53, SRC, MAPK1, MAPK3, and HSP90AA1. The gene discussed is MAPK3; the disease is COVID-19.