The pathology mechanisms of PCOS is a vicious circle of hyperandrogenism facilitating abdominal visceral adiposity which aggravates androgen secretion of ovarian and/or adrenal origin by the direct modulation of cytokines such as tumor necrosis factor, interleukin 6, and leptin or the indirect induction of insulin resistance and hyperinsulinism (34). The gene discussed is TNF; the disease is Insulin resistance.