Androgen excess secretion is a prerequisite for PCOS development which arises from dysregulation of the hypothalamus-pituitary-ovary axis(HPOA), leading to sensitize ovarian steroidogenesis in response to enhancement of LH and P450c 17α-hydroxylase hyperactivity of follicular theca cells. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.