The observation that an imbalance ratio of LH/FSH is one of the common hormonal changes of HPOA function disorders and LH/FSH>2 may have enhanced the activity of adrenal-derived androgens, worsening hyperandrogenemia symptoms such as hirsutism and acne in PCOS patients (4, 29). The gene discussed is PLOD1; the disease is Hirsutism.