VLDLR and nonpapillary renal cell carcinoma: Specifically, increased cholesterol uptake by upregulated lipoprotein receptors, such as the very low-density lipoprotein receptor (VLDL-R) (63) and scavenger receptor B1 (SR-B1) (64), and the expression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) contribute to the accumulation of cholesterol in ccRCC (62).