In multivariate analysis to assess whether models contain the agents (TCT) and the confounding factors, young-old quartile age, and several agents, Table 3 showed the agents to be significantly correlated with the incidence of dry eye, subjective visual disturbances, and finding of any toxicity; HER2 inhibitors were still significantly correlated with findings of dry eye (p < 0.001, odds ratio = 5.41, 95% CI = 2.56-11.36), as was ICI (p < 0.001, odds ratio = 2.74, 95% CI = 1.60-4.70). Here, ERBB2 is linked to Keratoconjunctivitis sicca.