TRPM2 and cancer: For example, hypermethylated promoters of transmembrane protein 240 (TMEM240) and HAGLR opposite strand lncRNA (HAGLROS) were observed in the cancer cells of most patients (11/14), while hypomethylated promoters of TRPM2-AS and histamine receptor H1 (HRH1) were observed in the cancer cells of 10/14 patients.