MUC1 and neuroendocrine carcinoma: For example, mucin 1 (MUC1), which is a member of the mucin family, significantly down-regulated in ADC with poorer differentiation states than in ADC with better differentiation states, and significantly down-regulated in non-ADC (NEC and HAS) compared with ADC within the same mGC patient (Fig. 4A), which was also validated by IHC staining at protein levels (Fig. 4B).