MIB1 and cancer: Our protein–protein quantitative proteomics and Western blot evaluation published that cure with SC notably decreased the expression of the E3 ubiquitin ligase MIB1, which acted as an E3 ubiquitin ligase to promote the proteasomal degradation of numerous proteins such as NRF2 and ST7 to feature in some cancers, thereby affecting tumor increase and improvement.25, 26