In this experimental study, co-administration of the cannabinoid type 1 receptor blocker, rimonabant, with antiretroviral drugs known to produce insulin resistance (LPV/r+AZT), resulted in significantly higher insulin sensitivity in Sprague Dawley rats as determined by calculation of area under curve of graphs of blood glucose concentration plotted against time following a two-hour insulin tolerance test. The gene discussed is INS; the disease is Insulin resistance.