De Oliveira Ribeiro et al. compared depression and anxiety in patients with RA who were prescribed different medications and showed that treatment with biologic DMARDs (such as TNF-α antagonists) contributed to more patients with higher scores for depression when compared to patients treated with conventional DMARDs (such as methotrexate, leflunomide, and hydroxychloroquine) (11). Here, TNF is linked to depressive disorder.