De Oliveira Ribeiro et al. compared depression and anxiety in patients with RA who were prescribed different medications and showed that treatment with biologic DMARDs (such as TNF-α antagonists) contributed to more patients with higher scores for depression when compared to patients treated with conventional DMARDs (such as methotrexate, leflunomide, and hydroxychloroquine) (11). The gene discussed is TNF; the disease is major depressive disorder.