So, transferrin is one of the most investigated ligands for nanoparticles functionalization, to achieve a targeted drug delivery: the possibility to enrich protein corona in transferrin could be crucial to efficiently target nanoparticles into tumor sites or to promote the crossing of the blood–brain barrier for the treatment of brain disorders (Choudhury et al. 2018; Sepand et al. 2020). The gene discussed is TF; the disease is neoplasm.