The RNA sequencing data from C9orf72 ALS/FTD human tissue, similar to C9orf72 ALS/FTD iPSC-MG, did not show apparent differences in genes related to homeostatic, interferon, activated, or NF-κB pathways (Supplementary Figures S3E–H). Here, C9orf72 is linked to amyotrophic lateral sclerosis.