Further studies are necessary to determine if C9orf72 ALS/FTD iPSC-MG present or exacerbate an inflammatory phenotype when stimulated to induce more specific inflammatory responses, such as activation of the inflammasome via the NLRP pathway (Fu et al., 2022; Trageser et al., 2023) or co-stimulation of LPS and IFNγ to specifically activate pro-inflammatory pathways (Kann et al., 2022). Here, C9orf72 is linked to amyotrophic lateral sclerosis.