These results confirm the ability of C9orf72 ALS/FTD patient-derived iPSC-MG mono-cultures to respond to extracellular stimuli and support previous in vitro studies showing no significant changes in inflammatory responses in murine microglia cell lines overexpressing C9orf72 HRE (Rostalski et al., 2020). The gene discussed is C9orf72; the disease is frontotemporal dementia.