The absence of TDP-43 and ADAR2 mislocalization could be due to the cellular age of the differentiated cells, as recent human postmortem tissue studies suggested that TDP-43 mislocalization is a late-stage event of C9orf72 ALS pathogenesis (Vatsavayai et al., 2016). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.