Upon LPS stimulation, both control and C9orf72 ALS/FTD iPSC-MG mono-cultures exhibited increased release of IL1α, IL1β, IL6, and TNFα compared to basal conditions but no differences between the experimental groups were observed (Figures 4A–D; individual cell response shown in Supplementary Figures S5A–D). Here, IL1B is linked to amyotrophic lateral sclerosis.