Additionally, curcumin reduces blood glucose by upregulating the expression of the glucose transporter type 4 (GLUT4), GLUT2, and GLUT3 genes, activating AMP kinase, promoting peroxisome proliferator-activated receptor (PPAR) ligand-binding activity, stimulating insulin secretion from pancreatic tissues, improving pancreatic cell function, and lowering insulin resistance [95]. The gene discussed is INS; the disease is Insulin resistance.