By causing the release of tissue necrotic factor-alpha (TNF-a), interleukin 6 (IL-6), and interleukin 12 (IL-12), which are essential for attracting monocytes to adhere to endothelial cells, LOX-1, a pro-inflammatory receptor, raises the risk of CVDs in SLE [9]. The gene discussed is IL6; the disease is systemic lupus erythematosus.