PLOD1 and polycystic ovary syndrome: Polycystic ovary syndrome (PCOS) is a constellation of endocrinopathy characterized by infertility, menstrual dysregulation, hyperandrogenemia, acanthosis nigricans, and a hormone profile revealing increased luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio, hyperinsulinemia, elevated androgen levels, obesity, and dyslipidemia.