Functional enrichment analysis of IRDGs and LRDGs revealed KEGG (Supplementary Figures 2B–D) enrichment in alcoholic liver disease, hepatitis B, cytokine-cytokine interactions, fat digestion and absorption, choline metabolism in cancer, PPAR signaling pathway, IL-17 signaling pathway, the interaction of viral proteins with cytokines as well as cytokine receptors, and natural killer cell-mediated cytotoxicity. This evidence concerns the gene PPARA and hepatitis B virus infection.