M2 macrophages, which are induced with IL-13 and IL-4, highly express CD206, increase endocytosis and secrete the anti-inflammatory cytokines, for instance TGF-β and IL-10, facilitate Th2 cell differentiation, and participate in immune regulation, repair function, wound healing, angiogenesis, and promote tumor progression. The gene discussed is TGFB1; the disease is neoplasm.