Subgroup analysis on the basis of clinical features revealed that the expression of risk factors DGAT2L6, GAL, KIF18A, STC2, and SPP1 in the prognostic signature was positively linked to the tumor stage (paradoxically, low expression of DGAT2L6 and KIF18A in tumor stage IV may be owing to the sample size being small). This evidence concerns the gene SPP1 and neoplasm.