AFP and neoplasm: Multivariate Cox regression analyses revealed that ≥4 (vs. <4) tumors (adjusted hazard ratio [HR], 2.96; p < 0.001), tumor size >10 cm (vs. ≤10 cm) (adjusted HR, 1.63; p = 0.003), Child–Pugh class B (vs. class A) (adjusted HR, 2.12; p < 0.001), AFP concentration ≥400 ng/mL (vs. <400 ng/mL) (adjusted HR, 1.62; p = 0.003), and tumor rupture before TACE (vs. no tumor rupture) (adjusted HR, 1.55; p = 0.037) were significantly associated with OS rates (Table 2).