The majority of SLE-associated variants do not interact with the closest gene but rather with distant promoters, many of which have been implicated in TFH and SLE, including BCL6 and CXCR5. Additionally, genes whose role in TFH/SLE disease biology was previously unknown were discovered through the combination of GWASs and 3D genomics. The gene discussed is BCL6; the disease is systemic lupus erythematosus.