ERN1 and neoplasm: To gain insights in the role of the IRE1/XBP1s axis in tumor DC biology, we generated double conditional knock-out mice lacking the IRE1 RNase domain and XBP1s in CD11c-expressing cells by crossing the Itgax-Cre mice line with Xbp1fl/fl and Ern1fl/fl floxed mice lines (35–37) (referred to as “XBP1ΔDCIRE1truncDC mice”); and single conditional knock-out mice (referred to as “XBP1ΔDC mice”) lacking XBP1s in CD11c-expressing cells (see methods for details).