Whereas tumor cDC1s from control mice displayed high levels of Xbp1 spliced mRNA (Figure 2C), tumor cDC1s isolated from XBP1ΔDCIRE1truncDC mice were unable to induce Xbp1 splicing due to the lack of a functional IRE1 RNase domain (Figure 2C). The gene discussed is ERN1; the disease is neoplasm.