Analysis revealed that XBP1ΔcDC1IRE1trunc-cDC1 mice showed normal B16ChOVA melanoma tumor growth (Figure 4A), and normal CD8+/CD4+ T cell tumor infiltration and function compared to control littermates, and a modest decrease in TNF+ CD8+ T cells (Figure 4B, Supplementary Figure 8E). This evidence concerns the gene TNF and melanoma.