ERN1 and neoplasm: Here, we report a broad approach for studying the role of the IRE1/XBP1s axis in tumor DCs/cDC1s, by using a combination of two different immunoresponsive tumor models, two different conditional Cre lines for selective deletion in the DC or cDC1 compartment respectively, plus single and double deletion of the IRE1/XBP1s axis.