CD8A and melanoma: Interestingly, the reduced frequencies of effector T cells in B78ChOVA tumors from XBP1ΔDC mice were not associated with defective cross-presentation of a model antigen in melanoma, as XBP1WT and XBP1ΔDC mice lines contained similar frequencies of endogenous OVA-specific CD8+ T cells in TdLN and tumors (Supplementary Figure 6E, F).