Also, cDC1, cDC2 and TAMs from melanoma tumors of XBP1ΔDC mice expressed normal levels of PD-L1 (Figure 3J), an immunoregulatory molecule target of checkpoint blockade therapy which expression is attributed to the IRE1/XBP1s axis in tumor macrophages (28). The gene discussed is MPPE1; the disease is neoplasm.