Here, we sought to reveal the functional role of the IRE1/XBP1s axis in tumor cDCs in two immunoresponsive models: subcutaneous mouse B16/B78 melanoma and MC38 colon adenocarcinoma (2, 30) using a combination of single and double deficiency for IRE1 RNase and/or XBP1s driven by two conditional knock-out systems for deletion in the whole DC compartment or exclusively in cDC1s. The gene discussed is ERN1; the disease is colon adenocarcinoma.