In fact, tumor cDC1s, cDC2s and TAMs from XBP1ΔDC mice display signs of RIDD at protein level, as surface expression of the integrin CD11c, an obligate dimeric partner of the RIDD substrate Itgb2 (coding the integrin CD18) (21) is reduced in tumor cDC1s from XBP1ΔDC mice (Supplementary Figure 6G). The gene discussed is ITGB2; the disease is neoplasm.