Apart from tumor-expressed lncRNAs that impair effector CD8+ T cells (88, 89, 92, 137, 150), several lncRNAs have been described that induce an immunosuppressive TME by altering tumor-infiltrating CD4+ T cells (137, 159), Tregs (88, 129, 137, 159, 160), γδ T cells (82, 83) and NKT cells (70). This evidence concerns the gene CD8A and neoplasm.