To identify putative p38β substrates that may explain the mechanism by which p38β promotes infection, we created an analysis pipeline to assess proteome and phosphoproteome data from experiments employing three different p38β perturbation strategies: (1) siRNA knockdown of p38β (described previously), (2) titrated treatment of cells with the p38ɑ/β inhibitor SB203580 beginning 1 hour before a 24-hour SARS-CoV-2 infection (pre-treatment), and (3) a 24-hour SARS-CoV-2 infection with the last four hours being in the presence of SB203580 (terminal treatment) (Fig. 5A). Here, MAPK11 is linked to infection.