Even prolonged pre‐treatment had almost no destructive effect on hair samples, although it may be noted that the study authors tested highly rigid, cell‐free samples.[100] The dinuclear gold(III) compound A12 was found to reduce the expression of cytoskeletal proteins in cisplatin‐resistant ovarian cancer cells (A2780/R), especially two keratins (type I and II), but this effect was not further evaluated.[81] Moreover, cytokeratin 18 (CK18) was significantly upregulated upon treatment of HCT116 colon cancer cells with the organoruthenium complex plecstatin‐1 and affected the IF network.[4c]. This evidence concerns the gene KRT18 and colonic neoplasm.