Notably, a recent publication suggests that absolute numbers of peripheral blood CD4+ Tregs, PD-1–positive CD8+ T cells, and CTLA-4–positive Tregs are increased in patients with ADPKD compared with healthy controls, paralleling our findings and providing additional relevance of our study to the human disease (67). The gene discussed is CD8A; the disease is autosomal dominant polycystic kidney disease.