CD8A and autosomal dominant polycystic kidney disease: Further, urinary CD4+ T cell numbers were reported to correlate with renal function loss in patients with ADPKD, and we have shown that, correlative with disease severity, both CD4+ and CD8+ T cell numbers increase in cystic kidneys of an orthologous ADPKD mouse model and specifically localize to cystic lesions (10, 11).